Medication guide according to the use of

Nizagara over the counter instructions

Active element : Sildenafil salt (sildenafil citrate)

Purpose: The product to increase potency or cure erectile dysfunction

Release form: The pills are covered with a pale blue layer , have a diamond – shaped configuration , a bit plastic .

Nizagara over the counter will be released in a dose of : TWENTY-FIVE mg,FIFTY mg, 100 mg

Ingredients of Nizagara over the counter: polymer , dry calcium phosphate , magnesium stearate, croscarmellose sodium, film spraying .

International name : sildenafil (sildenafil).

Download the guide according to the use of the substance Nizagara over the counter

Dosage and prescriptions according to the use : It is taken inside , because of the TWENTY – THIRTY min. down to sexual activity (1pill ). Taking into account personal tolerance, it is possible to reduce the dose up to FIFTY or TWENTY-FIVE mg. A suitable daily dose is SRT mg and is taken no more than once a day.

The effect of

Sildenafil is considered to be a strong and tested substance in order to cure erectile dysfunction in the stronger sex . Selection diphenyl laminec GMP peculiar phosphodiesterase 5 (fde5).

Nizagara over the counter operates only the presence of the presence of sexual stimulation

Sildenafil any manner does not exhibit immediate soothing effect in cavernous shape , but the medicine increases soothing result NO nitric oxide in this material with the support of inhibiting PDE-5, which is responsible for the destruction ofcGMP in the cavernous torso .

Inhibition of PDE5 about the influence of sildenafil results in an increase in the degree of cGMP in the cavernous body , the result of which the same is accomplished slackness gladenkie muscle and increase blood flow to the sexual member.

Nizagara over the counter

In individual patients by one time even after the process substance medication in dose SRT mg, existeda simple failure to distinguish the colors of the colors (blue / green) was revealed . By 2 minutes after the mode of substance, these secondary results were lacking .

Pharmacokinetics

The pharmacokinetics of sildenafil is in dependence with the established dose: with twenty-five mg until SRT mg per day / p>

Induction period in blood

sildenafil contains enough significant absorbencyin krovushka . After the process 1 in tablekti SRT mg sildenafil highest concentration of substances in month equal 18 ng / ml (38nM) in the case where after the product was taken in the absence of food intake , the concentration achieves a stretch with THIRTY up to sixty minutes. .

In general use with greasy food , absorption periodThe intensive element of sildenafil in the blood rises approximately in the THIRTY min. , and the maximum concentration in the monthly decreases in 29%

Metabolism

In the main, sildenafil, about the influence of CYP3A4 ( main approach ) and CYP2C9 ( minor approach ) of microsomal liver isoenzymes. Monthly plasma metabolite concentration is approximately 40% with such sildenafil.

N-desmethylmetabolite undergoes further metabolism; its terminal T1 / 2 equal to about 4 times .

Output from the organism

total period conclude the sildenafil with body equal to 3-5 times , after the process inside the medicine gets to embodiment metabolites potassom 80% in the urine of approximately 13

Indications

Erectile dysfunction ,inability to recruit or maintain an erection, necessary for the purpose in accordance with the norm of sexual action . The medicine is specialized only for the purpose of the representatives of the stronger sex , but a lady’s medicine exists .

Dosage

The drug is received inside with a large amount of water . A suitable initial dose is the same FIFTY mg due to THIRTY -SIXTY min. up to the alleged sexual contact. Taking personal results into account, it is possible to increase the dose up to 100 mg or reduce it up to TWENTY-FIVE mg. Carry Nizagara over the counter no more than 1 once a day . In case of serious renal failure (QA< THIRTY ml / min), the dose should be reduced to TWENTY-FIVE mg. Presence simple and typical levels of renal failure dose adjustment is not necessary .

The combined use of sildenafil with ritonavir is allowed only the presence of the highest dose of sildenafil of the same TWENTY-FIVE mg, no more than 1 time in 48 times .

In general use with similar substances , as well as : saquinavir, ketoconazole, medicineItraconazole – The initial allowable dose is TWENTY-FIVE mg.

Side Effects

The manifestation of unnecessary secondary effects increases with increasing dose. The concept of organizations and the possibility of occurrence of minor results with sildenafil (in%) of

Nizagara over the counter

frequent secondary effects :

  • Headache suffering TEN .8
  • cardiovascular vennaya concept ( inflows monthly to the person ) TEN .9
  • Dizziness 2.9
  • Changes in vision ( change receptivity to the world , clouding of vision ) 2.5

Digestive concept :

  • Dyspepsia 3.0
  • Hromatopsiya ( change the perception of colors colors ) 1.1
  • Rapid heartbeat 1.0
  • rhinitis ( rhinitis ) 2.1
  • In case of overdose the possibility of minor results rapidly increases

 

Increased susceptibility of the skin (in this amount, rash in the skin ).

Tachycardia, reduction in blood pressure, fainting.

  • Redness of the eye , suffering in observations .
  • Prolonged or painful arousal .
  • Contraindications to the use of nizagara over the counter

Increased susceptibility and intolerance to the components of the substance . The drug is contraindicated to use.in the representatives of the stronger sex , receiving donators of nitric oxide and nitrates in various configurations , since sildenafil increases the effect of nitrates.

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